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MultimediaMost patients with major depressive disorder will not achieve remission with initial treatment. Strategies to increase the likelihood of achieving remission include regularly measuring response, assessing adverse effects and adherence, addressing non-mood symptoms, and knowing when to switch or augment antidepressants. In this CME Health Spectrum activity, follow 2 patient cases that illustrate these topics. [top]

Advanced Topics in Major Depressive Disorder: Practical Strategies to Improve Remission

Advanced Topics in Major Depressive Disorder: Practical Strategies to Improve Remission

Rakesh Jain, MD, MPH

Enhancing Approaches to the Identification and Management of Pseudobulbar Affect

Enhancing Approaches to the Identification and Management of Pseudobulbar Affect

David W. Crumpacker, MD

Improving the Care and Management of Patients With Inadequate Response to Depression Treatment

Managing Medical Comorbidities in Patients With Depression to Improve Overall Prognosis

Michael E. Thase, MD

Identifying Patients Who Need a Change in Depression Treatment and Implementing That Change

George I. Papakostas, MD

Implementing Appropriate Treatment Strategies for Varying Types of Depression

Roger S. McIntyre, MD, FRCPC

Recognizing and Assessing Risk Factors for Difficult-to-Treat Depression and Treatment-Resistant Depression

Bradley Gaynes, MD, MPH

Achieving Remission and Recovery in Depression With Anxiety

The Role of Insomnia in Depression and Anxiety: Its Impact on Functioning, Treatment, and Outcomes

Andrew J. Cutler, MD

Importance of Restoring Function in Patients With Major Depressive Disorder

David V. Sheehan, MD, MBA

Impact of Anxious Symptoms and Comorbid Anxiety Disorders on Functional Impairment in Depressed Patients

Larry Culpepper, MD, MPH

Sleep Disorders in the Psychiatric Setting

Recognizing and Managing Insomnia in Primary Care and Specialty Settings

Andrew D. Krystal, MD, MS (chair), and Adam J. Sorscher, MD

What Psychiatric Nurses Need to Know About Bipolar Disorder

Engaging Patients in Long-Term Management of Bipolar Disorder

Joanne DeSanto Iennaco, PhD, PMHNP-BC, APRN, and Julie A. Carbray, PhD, FPMHNP-BC, PMHCNS-BC, APRN

Communicating With Colleagues and Patients About Acute Bipolar Disorder

Joanne DeSanto Iennaco, PhD, PMHNP-BC, APRN, and Julie A. Carbray, PhD, FPMHNP-BC, PMHCNS-BC, APRN

Recognizing Signs and Symptoms of Bipolar Disorder

Julie A. Carbray, PhD, FPMHNP-BC, PMHCNS-BC, APRN, and Joanne DeSanto Iennaco, PhD, PMHNP-BC, APRN

Barriers to Remission in Major Depressive Disorder: Residual Symptoms, Functional Impairment, and Medication Mechanism of Action

Neurobiology of Depression and Mechanism of Action of Depression Treatments

Pierre Blier, MD, PhD

Functional Impairment and Improvement in Depression

Larry Culpepper, MD, MPH

Residual Symptoms in Depression: Prevalence and Impact

Andrew A. Nierenberg, MD

Using Mechanism of Action to Choose Medications for Treatment-Resistant Depression

Why Is Mechanism of Action Important in Antidepressant Treatment?

Thomas L. Schwartz, MD

How Does Understanding Mechanism of Action Help Clinicians Personalize Antidepressant Treatment Choices?

Michael E. Thase, MD

What Are the Mechanisms of Action of Current Antidepressant Treatments?

Michael E. Thase, MD

Criminal Forensic Psychiatry

Criminal Forensic Psychiatry: A Primer for Psychiatrists

Scott A. Freeman, MD

Strategies to Improve Outcomes for Primary Care Patients With Major Depressive Disorder

Tactics to Improve Adherence in Depressed Primary Care Patients

C. Brendan Montano, MD

The Benefits of Measurement-Based Care for Primary Care Patients With Depression

W. Clay Jackson, MD, DipTh

The Identification and Resolution of Residual Symptoms in Depressed Primary Care Patients

Rakesh Jain, MD, MPH

Recognizing and Treating Excessive Daytime Sleepiness and Narcolepsy

Recommended Treatment Strategies for Patients With Excessive Daytime Sleepiness

Russell P. Rosenberg, PhD

Clinical Assessment of Excessive Daytime Sleepiness in the Diagnosis of Sleep Disorders

Russell P. Rosenberg, PhD

Effects of Excessive Daytime Sleepiness and Fatigue on Overall Health and Cognitive Function

Thomas Roth, PhD

The Effect of Comorbid Psychiatric and Medical Illnesses on Sleep Disorder Treatment

Thomas Roth, PhD

Understanding and Coping With Binge Eating Disorder: The Patient’s Perspective

Understanding and Coping With Binge Eating Disorder: The Patient’s Perspective

Susan L. McElroy, MD (chair), and Anna I. Guerdjikova, PhD, LISW, CCRC

Cause and Effect in Bipolar Depression: Misdiagnosis Leads to Inappropriate Treatment, Clinical Complications, and Adverse Outcomes

Consequences of Misdiagnosis: Inaccurate Treatment and Poor Patient Outcomes in Bipolar Disorder

Henry A. Nasrallah, MD

Effective Treatment of Bipolar Depression: Monotherapy and Combination Strategies

J. Sloan Manning, MD

Setting the Stage for Success or Failure: Making an Accurate Diagnosis of Bipolar Depression

Henry A. Nasrallah, MD

Improving Depression Outcomes by Providing Safe and Effective Care in the Rural Setting

Providing Guideline-Concordant Assessment and Monitoring for Major Depression in Primary Care

J. Sloan Manning, MD, and W. Clay Jackson, MD, DipTh

Treating Depression in Primary Care: Initial and Follow-Up Treatment Strategies

J. Sloan Manning, MD, and W. Clay Jackson, MD, DipTh

Treating and Caring for the Patient With Moderate-to-Severe Alzheimer's Disease

Effective Communication Strategies to Help Patients and Caregivers Cope With Moderate-to-Severe Alzheimer’s Disease

Jan Dougherty, RN, MS

Managing Patients With Moderate-to-Severe Alzheimer’s Disease: Expectations, Treatments, and Prognosis

William J. Burke, MD

Overcoming Challenges in the Diagnosis and Management of ADHD in African American Adults

Health Care–Seeking Behaviors of African American ADHD Patients and Their Families: Overcoming Economic and Cultural Barriers

Anthony L. Rostain, MD

Health Care Systems Issues and Disparities in ADHD Care for African American Adults

J. Russell Ramsay, PhD

Culturally Competent Approaches to Assessing ADHD in African American Adults and Overcoming Cultural Issues With Patients and Families

Roberta Waite, EdD, PMHCNS-BC, FAAN

Challenges in the Recognition and Management of ADHD in Hispanic Adults in the United States

Cultural Issues, Myths, Misinformation, and Health Care–Seeking Behaviors of Hispanic Patients With ADHD and Their Families

Anthony L. Rostain, MD

Culturally Competent Approaches to Diagnosing ADHD in Hispanic Adults and Overcoming Cultural Issues With Patients and Families

Juan Pedraza, MD

Health Care Systems Issues and Disparities in ADHD Care for Hispanic Adults

Yamalis Diaz, PhD

The Impact of Oral Medications on the Treatment of Multiple Sclerosis

Switching Therapies in MS: What Are the Options?

Clyde E. Markowitz, MD

Identifying and Addressing Unmet Therapeutic Needs in MS

Clyde E. Markowitz, MD

Current Standards of Treatment in MS and the Role of Oral Agents

Harold Moses, Jr, MD

Recognizing and Overcoming Potential Barriers to Oral Medications for MS

Harold Moses, Jr, MD

Controversies in the Psychopharmacology of Bipolar Disorder

Controversies in the Psychopharmacology of Bipolar Disorder

Robert M. Post, MD (Chair), et al

Appropriate Management of Multiple Sclerosis in Primary Care

Developing a Therapeutic Plan for MS: Evidence for New Treatments

Michael C. Levin, MD, and W. Clay Jackson, MD, DipTh

Diagnosing MS: Recognizing Common Symptoms and Interpreting MRI Results

Michael C. Levin, MD, and W. Clay Jackson, MD, DipTh

Making Connections Between Science and Symptoms in Schizophrenia

Schizophrenia: Overview and Dopamine Dysfunction

Anissa Abi-Dargham, MD

The Role of NMDA Receptors in Schizophrenia

John M. Kane, MD

Mechanism of Action of Antipsychotic Medications

Christoph U. Correll, MD

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