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Improving the Care and Management of Patients With Inadequate Response to Depression Treatment

Bradley Gaynes, MD, MPH; Roger S. McIntyre, MD, FRCPC; George I. Papakostas, MD; and Michael E. Thase, MD

Only about one-third of patients with depression respond to their initial treatment trial, so clinicians face the challenge of managing patients with poor response or treatment-resistant depression. In this Supplement, learn to identify difficult-to-treat types of depression, to select evidence-based treatments, to adjust treatment in a timely manner, and to coordinate care of comorbid conditions to improve patient outcomes.

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